Factors influencing quality of life in adult patients with
primary brain tumors
Rakesh Jalali and Debnarayan Dutta
NeuroOncology Group, Tata Memorial Hospital, Mumbai, India
(R.J.); Apollo Specialty Hospital, Chennai,
India (D.D.)
We performed a literature reviewwith respect to factors
influencing health-related quality of life (QOL) in adults with
primary brain tumors. A comprehensive, peer-reviewed literature
search was performed including studies examining
QOL in adults with high-grade gliomas and lowgrade gliomas and
in routine neuro-oncology practice. The interpretation and implication of QOL
domain scores may be different in high-grade, low-grade, and benign brain
tumors. Several patient-related, treatment-related, and sociocultural factors
influence QOL scores. Pretreatment baseline QOL domain scores have been shown
to be a predictive parameter for survival function. Implementation of QOL
scores in routine clinical practice is underused. QOL is an important outcome measure
in the treatment of patients with brain tumors and should be incorporated as a
surrogate end point along with traditional end points, such as disease-free and
overall survival in most current trials.
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